Bone marrow transplantation in precocious osteopetrosis.
نویسندگان
چکیده
منابع مشابه
Malignant osteopetrosis: hypercalcaemia after bone marrow transplantation
Discussion In this case engraftment was followed by a rapid rise in the calcium concentration, and hypercalcaemia recurred on a number of occasions. A management plan to control the serum calcium concentration during these acute phases and to maintain long term normocalcaemia evolved with experience. In the acute phase the hypercalcaemia seemed to be controlled primarily by a combination of reh...
متن کاملMalignant osteopetrosis: hypercalcaemia after bone marrow transplantation.
A 3 year old girl presented with malignant osteopetrosis, which was treated by allogeneic bone marrow transplantation. Successful engraftment was complicated by prolonged hypercalcaemia, which was controlled by a combination of a bisphosphonate, phosphate infusions, vigorous resalination, and salmon calcitonin. She was alive and well 16 months after the transplant.
متن کاملImportance of neurological assessment before bone marrow transplantation for osteopetrosis.
Neurological complications of malignant infantile osteopetrosis are well recognised; successful bone marrow transplantation, when performed early in life, can prevent or halt some of them. In a subgroup of infants osteopetrosis is associated with primary retinal degeneration and/or generalised neurodegeneration. Bone marrow transplantation, in spite of being successful in correcting the osseous...
متن کاملALLOGENIC BONE MARROW TRANSPLANTATION IN APLASTIC ANEMIA
Eighteen patients, twelve men and six women, with aplastic anemia underwent allogenic bone marrow transplantation (BMT) from HLA-matched siblings during the period of 1990 to 1996. The conditioning regimen was cyclophosphamide with or without busulfan, depending on the cause of aplasia. Antilymphocyte globulin (ALG) and cyclosporine were used for rejection and acute GVHD prophylaxis, respe...
متن کاملInfantile osteopetrosis; bone marrow transplantation from a cousin donor.
The successful correction of infantile osteopetrosis in an Asian child by bone marrow transplantation (BMT) from an HLA-A,B matched cousin donor is reported. Retrospective HLA molecular analysis revealed that patient and donor were incompatible for HLA-DPB1. Donor type cells detected in the patient after transplantation indicate successful engraftment. The patient is currently alive and well.
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ژورنال
عنوان ژورنال: BMJ
سال: 1987
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.294.6570.463